Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose
regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient …

Recent developments in stem cell biology have enabled the study of cell fate decisions in
early human development that are impossible to study in vivo. However, understanding how …

Establishment of a functional vascular network is rate-limiting in embryonic development,
tissue repair and engineering. During blood vessel formation, newly generated endothelial …

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …

A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is …

Mammalian cells stably maintain high levels of DNA methylation despite expressing both
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …

Stem cells undergo cellular division during their differentiation to produce daughter cells
with a new cellular identity. However, the epigenetic events and molecular mechanisms …

Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and
were proposed to regulate phenotypic maintenance of stem and progenitor cells at the …