ω-3 and ω-6 polyunsaturated fatty acids, obesity and cancer

S D'Angelo, ML Motti, R Meccariello - Nutrients, 2020 - mdpi.com
Recently, nutraceutical bioactive compounds in foods have been discovered for their
potential health benefits regarding the prevention of chronic disorders, such as cancer, and …

Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications

I Khan, M Hussain, B Jiang, L Zheng, Y Pan, J Hu… - Progress in lipid …, 2023 - Elsevier
Abstract Recently, omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have
gained substantial interest due to their specific structure and biological functions. Humans …

Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy

D D'Eliseo, F Velotti - Journal of clinical medicine, 2016 - mdpi.com
Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional
cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development …

Beyond heat stress: intestinal integrity disruption and mechanism-based intervention strategies

P Lian, S Braber, J Garssen, HJ Wichers, G Folkerts… - Nutrients, 2020 - mdpi.com
The current climate changes have increased the prevalence and intensity of heat stress (HS)
conditions. One of the initial consequences of HS is the impairment of the intestinal epithelial …

Metabolism-based therapeutic strategies targeting cancer stem cells

P Jagust, B de Luxán-Delgado… - Frontiers in …, 2019 - frontiersin.org
Cancer heterogeneity constitutes the major source of disease progression and therapy
failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) …

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

SF Nabavi, S Bilotto, GL Russo, IE Orhan… - Cancer and Metastasis …, 2015 - Springer
Over the past decades, extensive studies have addressed the therapeutic effects of omega-3
polyunsaturated fatty acids (omega-3 FAs) against different human diseases such as …

Resveratrol chemosensitizes TNF-β-induced survival of 5-FU-treated colorectal cancer cells

C Buhrmann, M Yazdi, B Popper, P Shayan, A Goel… - Nutrients, 2018 - mdpi.com
Objective: Resveratrol, a safe and multitargeted natural agent, has been linked with
inhibition of survival and invasion of tumor cells. Tumor Necrosis Factor-β (TNF …

Cancer metabolism as a therapeutic target and review of interventions

MTJ Halma, JA Tuszynski, PE Marik - Nutrients, 2023 - mdpi.com
Cancer is amenable to low-cost treatments, given that it has a significant metabolic
component, which can be affected through diet and lifestyle change at minimal cost. The …

Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer

M Volpato, MA Hull - Cancer and Metastasis Reviews, 2018 - Springer
The majority of evidence linking anti-colorectal cancer (CRC) activity with omega-3
polyunsaturated fatty acids (O3FAs) has focussed on decreased CRC risk (prevention) …

Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT

C Buhrmann, P Kraehe, C Lueders, P Shayan, A Goel… - PloS one, 2014 - journals.plos.org
Objective Interaction of stromal and tumor cells plays a dynamic role in initiating and
enhancing carcinogenesis. In this study, we investigated the crosstalk between colorectal …