[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)

YY Qiu, J Zhang, FY Zeng, YZ Zhu - Pharmacological Research, 2023‏ - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …

Lipid metabolism and cancer

X Bian, R Liu, Y Meng, D **ng, D Xu, Z Lu - Journal of Experimental …, 2020‏ - rupress.org
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Saroglitazar, a PPAR‐α/γ agonist, for treatment of NAFLD: a randomized controlled double‐blind phase 2 trial

S Gawrieh, M Noureddin, N Loo, R Mohseni… - …, 2021‏ - Wiley Online Library
Background and Aims NAFLD is characterized by insulin resistance and dysregulated lipid
and glucose metabolism. Saroglitazar, a dual peroxisome proliferator activated receptor‐α/γ …

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

N Bougarne, B Weyers, SJ Desmet, J Deckers… - Endocrine …, 2018‏ - academic.oup.com
Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

L Chen, T Jiao, W Liu, Y Luo, J Wang, X Guo, X Tong… - Cell Stem Cell, 2022‏ - cell.com
Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease
(IBD), the role of hepatic BA metabolism in the pathogenesis of colitis is poorly understood …

[HTML][HTML] Short-and medium-chain fatty acids in energy metabolism: the cellular perspective

P Schönfeld, L Wojtczak - Journal of lipid research, 2016‏ - Elsevier
Short-and medium-chain fatty acids (SCFAs and MCFAs), independently of their cellular
signaling functions, are important substrates of the energy metabolism and anabolic …

[PDF][PDF] A systematic review of animal models of NAFLD finds high‐fat, high‐fructose diets most closely resemble human NAFLD

YR Im, H Hunter, D de Gracia Hahn, A Duret… - …, 2021‏ - Wiley Online Library
Background and Aims Animal models of human disease are a key component of
translational hepatology research, yet there is no consensus on which model is optimal for …

Fatty acid oxidation: An emerging facet of metabolic transformation in cancer

Y Ma, SM Temkin, AM Hawkridge, C Guo, W Wang… - Cancer letters, 2018‏ - Elsevier
Cancer cells undergo metabolic reprogramming such as enhanced aerobic glycolysis,
mutations in the tricarboxylic acid cycle enzymes, and upregulation of de novo lipid …

[HTML][HTML] Current review of increasing animal health threat of per-and polyfluoroalkyl substances (PFAS): harms, limitations, and alternatives to manage their toxicity

AF Peritore, E Gugliandolo, S Cuzzocrea… - International journal of …, 2023‏ - mdpi.com
Perfluorinated and polyfluorinated alkyl substances (PFAS), more than 4700 in number, are
a group of widely used man-made chemicals that accumulate in living things and the …

[HTML][HTML] Metabolic reprogramming, oxidative stress, and pulmonary hypertension

MD Pokharel, DP Marciano, P Fu, MC Franco… - Redox biology, 2023‏ - Elsevier
Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and
function. It is becoming increasingly clear that endothelial cell dysfunction significantly …