Normal tissue cells are generally not viable when suspended in a fluid and are therefore
said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments
through a variety of cytoskeletal linker proteins to mechanically connect intracellular and …

Binding of integrins to ligands provides anchorage and signals for the cell, making them
prime candidates for mechanosensing molecules. How force regulates integrin–ligand …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

Pregabalin (Lyrica™) is a new antiepileptic drug that is active in animal seizure models.
Pregabalin is approved in US and Europe for adjunctive therapy of partial seizures in adults …

Matrix and tissue rigidity guides many cellular processes, including the differentiation of
stem cells and the migration of cells in health and disease. Cells actively and transiently test …

Rolling adhesion on vascular surfaces is the first step in recruiting circulating leukocytes,
hematopoietic progenitors, or platelets to specific organs or to sites of infection or injury …

Integrins are αβ heterodimeric adhesion receptors that relay signals bidirectionally across
the plasma membrane between the extracellular matrix and cell-surface ligands, and …

Receptor-ligand bonds strengthened by tensile mechanical force are referred to as catch
bonds. This review examines experimental data and biophysical theory to analyze why …