The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …
transcription machinery. Classic models of transcription regulation focus on the recruitment …
Defining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
Functional specificity in biomolecular condensates revealed by genetic complementation
Biomolecular condensates are thought to create subcellular microenvironments that
regulate specific biochemical activities. Extensive in vitro work has helped link condensate …
regulate specific biochemical activities. Extensive in vitro work has helped link condensate …
[HTML][HTML] Phase separation in biology and disease; current perspectives and open questions
In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …
existence, formation, biological functions, and disease associations of membraneless …
Dissecting the biophysics and biology of intrinsically disordered proteins
Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular
information processing, including signaling, transcription, stress response, DNA repair …
information processing, including signaling, transcription, stress response, DNA repair …
Multivalency emerges as a common feature of intrinsically disordered protein interactions
EL Sipko, GF Chappell, RB Berlow - Current Opinion in Structural Biology, 2024 - Elsevier
Intrinsically disordered proteins (IDPs) use their unique molecular properties and
conformational plasticity to interact with cellular partners in a wide variety of biological …
conformational plasticity to interact with cellular partners in a wide variety of biological …
Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer
Biomolecular condensates, the membraneless cellular compartments formed by liquid–
liquid phase separation (LLPS), represent an important mechanism for physiological and …
liquid phase separation (LLPS), represent an important mechanism for physiological and …
Biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal loo** or high-density promoter localization
J Li, S Liu, S Kim, J Goell, ZA Drum… - Nucleic Acids …, 2025 - academic.oup.com
Protein intrinsically disordered regions (IDRs) are critical gene-regulatory components and
aberrant fusions between IDRs and DNA-binding/chromatin-associating domains cause …
aberrant fusions between IDRs and DNA-binding/chromatin-associating domains cause …
Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlap** but distinct
Aberrant formation of biomolecular condensates has been proposed to play a role in several
cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes …
cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes …