Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Y Zhao, M Shen, L Wu, H Yang, Y Yao, Q Yang… - Cell death & …, 2023 - nature.com
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

VEGF signaling: role in angiogenesis and beyond

P Shaw, SKD Dwivedi, R Bhattacharya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

Strontium-calcium doped titanium dioxide nanotubes loaded with GL13K for promotion of antibacterial activity, anti-Inflammation, and vascularized bone regeneration

F Jia, D Xu, Y Sun, W Jiang, H Yang, A Bian, Y Liu… - Ceramics …, 2023 - Elsevier
Poor osseointegration and postoperative bacterial infections are the main causes of clinical
failure of titanium (Ti) based implants. In this study, calcium (Ca) and strontium (Sr), which …

Discovery and mechanistic studies of dual-target hits for carbonic anhydrase IX and VEGFR-2 as potential agents for solid tumors: X-ray, in vitro, in vivo, and in silico …

SM Hefny, TF El-Moselhy, N El-Din… - Journal of Medicinal …, 2024 - ACS Publications
A dual-targeting approach is predicted to yield better cancer therapy outcomes.
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …

Recent development of VEGFR small molecule inhibitors as anticancer agents: A patent review (2021–2023)

J Zeng, Q Deng, Z Chen, S Yan, Q Dong, Y Zhang… - Bioorganic …, 2024 - Elsevier
VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that
promotes angiogenesis and vascular permeability. It plays a significant role in processes …

Unveiling the chemistry of citrus peel: insights into nutraceutical potential and therapeutic applications

H Munir, S Yaqoob, KA Awan, A Imtiaz, H Naveed… - Foods, 2024 - mdpi.com
The recent millennium has witnessed a notable shift in consumer focus towards natural
products for addressing lifestyle-related disorders, driven by their safety and cost …

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis …

SM Hefny, TF El-Moselhy, N El-Din, A Ammara… - European Journal of …, 2024 - Elsevier
Herein, we describe the design and synthesis of novel aryl pyrimidine benzenesulfonamides
APBSs 5a-n, 6a-c, 7a-b, and 8 as pazopanib analogues to explore new potent and selective …

[HTML][HTML] The role of eosinophil-derived neurotoxin and vascular endothelial growth factor in the pathogenesis of eosinophilic asthma

M Tota, J Łacwik, J Laska, Ł Sędek, K Gomułka - Cells, 2023 - mdpi.com
Asthma is a chronic complex pulmonary disease characterized by airway inflammation,
remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and …

Histopathological aspects of the prognostic factors for salivary gland cancers

H Nishida, T Kusaba, K Kawamura, Y Oyama, T Daa - Cancers, 2023 - mdpi.com
Simple Summary We describe the currently known histopathological aspects of the
prognostic factors for salivary gland cancers and discuss the genetics or molecules used as …

Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

J Zheng, J Jiang, Y Pu, T Xu, J Sun, Q Zhang… - … in Bioengineering and …, 2023 - frontiersin.org
Targeting tumor-associated macrophages (TAMs) has emerged as a promising approach in
cancer therapy. This article provides a comprehensive review of recent advancements in the …