Parkinson disease-associated cognitive impairment

D Aarsland, L Batzu, GM Halliday… - Nature reviews Disease …, 2021‏ - nature.com
Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting>
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …

Long-term outcomes of deep brain stimulation in Parkinson disease

P Limousin, T Foltynie - Nature Reviews Neurology, 2019‏ - nature.com
The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established
for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically …

Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning

A Boutet, R Madhavan, GJB Elias, SE Joel… - Nature …, 2021‏ - nature.com
Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces
marked clinical benefits when optimized. However, assessing the large number of possible …

The future of stem cell therapies for Parkinson disease

M Parmar, S Grealish, C Henchcliffe - Nature Reviews Neuroscience, 2020‏ - nature.com
Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

New evidence on the management of Lewy body dementia

JP Taylor, IG McKeith, DJ Burn, BF Boeve… - The Lancet …, 2020‏ - thelancet.com
Dementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body
dementia, are common neurodegenerative conditions. Patients with Lewy body dementia …

Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?

KA Jellinger, AD Korczyn - Advances in Surgical and Medical …, 2023‏ - taylorfrancis.com
The clinical features of dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD) are similar and include dementia, cognitive fluctuations, and (visual) hallucinations in …

Neural signatures of hyperdirect pathway activity in Parkinson's disease

A Oswal, C Cao, CH Yeh, WJ Neumann… - Nature …, 2021‏ - nature.com
Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …

Neuroprosthetics: from sensorimotor to cognitive disorders

A Gupta, N Vardalakis, FB Wagner - Communications biology, 2023‏ - nature.com
Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …

Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies

KA Jellinger - Journal of neural transmission, 2018‏ - Springer
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

[HTML][HTML] Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing

IF Orlando, JM Shine, TW Robbins, JB Rowe… - Neuroscience & …, 2023‏ - Elsevier
Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …