A major breakthrough in neuroscience has been the realization in the last decades that the
dogmatic view of astroglial cells as being merely fostering and buffering elements of the …

As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used
as symptomatic therapy in several neurologic disorders. The improvement of visual function …

Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying
simultaneous activation of multiple neurons remains unknown. Epileptic discharges are in …

Large-conductance Ca2+-activated K+ channels (BK, also called Maxi-K or Slo channels)
are widespread in the vertebrate nervous system, but their functional roles in synaptic …

Background: Ca 2+ signals, elicited by cues from the oocyte and female tract, regulate
human sperm behavior. Results: CatSper channel activation (flagellum) and Ca 2+ store …

A paroxysmal depolarization shift (PDS) has been suggested to be a hallmark for epileptic
activity in partial-onset seizures. By monitoring membrane potentials and currents in pairs of …

STUDY QUESTION What is the prevalence of defects in the Ca2+-signalling pathways
mediating hyperactivation (calcium influx and store mobilization) among donors and sub …

We examined the occurrence of functional interactions between CB1 cannabinoid and μ
opioid receptors in the core of rat nucleus accumbens (NAc core). To that end, receptor …

Epilepsy is a common brain disorder, repeated seizures of epilepsy may lead to a series of
brain pathological changes such as neuronal or glial damage. However, whether circular …

Potassium channels dysfunction and altered genes encoding for molecules involved in
potassium homeostasis have been associated with human epilepsy. These observations are …