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CLIP and complementary methods
M Hafner, M Katsantoni, T Köster, J Marks… - Nature Reviews …, 2021 - nature.com
RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …
DDX3X: structure, physiologic functions and cancer
J Mo, H Liang, C Su, P Li, J Chen, B Zhang - Molecular cancer, 2021 - Springer
The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …
of RNA metabolism and participates in the progression of many diseases, including virus …
Mechanistic insights into precursor messenger RNA splicing by the spliceosome
Y Shi - Nature reviews Molecular cell biology, 2017 - nature.com
Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of
information from DNA to protein in all eukaryotes. Research over the past four decades has …
information from DNA to protein in all eukaryotes. Research over the past four decades has …
Mechanisms and regulation of alternative pre-mRNA splicing
Y Lee, DC Rio - Annual review of biochemistry, 2015 - annualreviews.org
Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …
regulation of gene expression, providing significant expansion of the functional proteome of …
Spliceosome structure and function
CL Will, R Lührmann - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein
(RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and …
(RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and …
The spliceosome: design principles of a dynamic RNP machine
MC Wahl, CL Will, R Lührmann - cell, 2009 - cell.com
Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its
regulation. Whereas most RNP enzymes are stable in composition and harbor preformed …
regulation. Whereas most RNP enzymes are stable in composition and harbor preformed …
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
M Hluchý, P Gajdušková, I Ruiz de los Mozos… - Nature, 2022 - nature.com
RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of
gene expression. It is controlled by the spliceosome, a megadalton RNA–protein complex …
gene expression. It is controlled by the spliceosome, a megadalton RNA–protein complex …
YB‐1 protein: functions and regulation
DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …
Structure of a yeast activated spliceosome at 3.5 Å resolution
Pre–messenger RNA (pre-mRNA) splicing is carried out by the spliceosome, which
undergoes an intricate assembly and activation process. Here, we report an atomic structure …
undergoes an intricate assembly and activation process. Here, we report an atomic structure …
Structure of a pre-catalytic spliceosome
C Plaschka, PC Lin, K Nagai - Nature, 2017 - nature.com
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and
extensive remodelling to form the spliceosome's catalytic centre. Here we report the cryo …
extensive remodelling to form the spliceosome's catalytic centre. Here we report the cryo …