Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …

Adult neurogenesis plays critical roles in maintaining brain homeostasis and responding to
neurogenic insults. However, the adult mammalian spinal cord lacks an intrinsic capacity for …

Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilize
during adulthood, ensuring lifelong hippocampal neurogenesis. We show that this …

Pioneer transcription factors have the unique and important role of unmasking chromatin
domains during development to allow the implementation of new cellular programs …

Pioneer transcription factors recognise and bind their target sequences in inaccessible
chromatin to establish new transcriptional networks throughout development and cellular …

Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs
during cell differentiation and reprogramming. Yet the protein structure domains that allow …

Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by
neoplastic stem cells that retain partial yet abnormal differentiation potential. Here, we show …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately
involved in learning and memory, mood, and stress response. Despite considerable …