Adeno-associated virus (AAV) has emerged as a leading platform for gene delivery for
treating various diseases due to its excellent safety profile and efficient transduction to …

Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …

To improve both the homogeneity and the stability of ADCs, we have developed site-specific
drug-conjugating reagents that covalently rebridge reduced disulfide bonds. The new …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

Nanotechnology, which deals with features as small as a 1 billionth of a meter, began to
enter into mainstream physical sciences and engineering some 20 years ago. Recent …

There has been a tremendous increase in the number of approved drugs derived from
recombinant proteins; however, their development as potential drugs has been hampered …

From life science to material science, to pharmaceutical industry, and to food chemistry,
polysulfides are vital structural scaffolds. However, there are limited synthetic methods for …

Background: Although various injected peptide and protein therapeutics have been
developed successfully over the past 25 years, several pharmacokinetic and immunological …

PEGylation is a versatile drug delivery technique that presents a particularly wide range of
conjugation chemistry and polymer structure. The conjugated protein can be tuned to …