The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

Highlights•Chromatin regulators orchestrate the pace and order of gene expression
programs in differentiating neurons.•Disease-associated mutations in chromatin regulators …

During mammalian embryogenesis, both the 5-cytosine DNA methylation (5meC) landscape
and three dimensional (3D) chromatin architecture are profoundly remodeled during a …

Abstract In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-
deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at …

DNA methylation (5mC) is an essential epigenetic mark associated with transcriptional
silencing. The role of 5mC in transcriptional repression is well established for a few hundred …

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by
progressive retinal ganglion cell (RGC) degeneration and vision loss. Since irreversible …

Recent advances in single‐cell transcriptomic data have greatly expanded our
understanding of both spermatogenesis and the molecular mechanisms of male infertility …

The seamless transition through stages of pluripotency relies on a balance between
transcription factor networks and epigenetic mechanisms. Here, we reveal the crucial role of …

DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in
regulating embryonic development, gene expression, adaption to environmental stress, and …

Background Establishment of DNA methylation (DNAme) patterns is essential for balanced
multi-lineage cellular differentiation, but exactly how these patterns drive cellular …