Succinate-directed approaches for Warburg effect-targeted cancer management, an alternative to current treatments?
A Casas-Benito, S Martínez-Herrero, A Martínez - Cancers, 2023 - mdpi.com
Simple Summary One hundred years ago, it was discovered that some cancer cells have a
different metabolism from normal cells. This alternative metabolism is called the Warburg …
different metabolism from normal cells. This alternative metabolism is called the Warburg …
Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance
S Imanaka, H Shigetomi, H Kobayashi - Reproductive Sciences, 2022 - Springer
The aim of this review is to summarize our current understanding of the molecular
mechanism for the glucose metabolism, especially pyruvate dehydrogenase (PDH), during …
mechanism for the glucose metabolism, especially pyruvate dehydrogenase (PDH), during …
Plectalibertellenone A suppresses colorectal cancer cell motility and glucose metabolism by targeting TGF‐β/Smad and Wnt pathways
CDB Gamage, JH Kim, R Zhou, SY Park, S Pulat… - Biofactors, 2025 - Wiley Online Library
Colorectal cancer (CRC) is the second most common cause of cancer‐related death and
represents a serious worldwide health problem. CRC metastasis decreases the survival rate …
represents a serious worldwide health problem. CRC metastasis decreases the survival rate …
[HTML][HTML] Role of glucose metabolism reprogramming in keratinocytes in the link between psoriasis and metabolic syndrome
L Yan, W Wang, Y Qiu, C Yu, R Wang, C Li - International …, 2024 - Elsevier
The mechanism linking psoriasis to metabolic syndrome (MetS) remains poorly understood.
Recent reports indicate upregulation of glycolysis-related proteins in psoriatic keratinocytes …
Recent reports indicate upregulation of glycolysis-related proteins in psoriatic keratinocytes …
Apigenin Suppresses the Warburg Effect and Stem‐like Properties in SOSP‐9607 Cells by Inactivating the PI3K/Akt/mTOR Signaling Pathway
Y Shi, K Lian, J Jia - Evidence‐Based Complementary and …, 2022 - Wiley Online Library
Osteosarcoma (OS) is a prevalent primary malignant bone tumor that commonly occurs in
children and adolescents. Apigenin (4′, 5, 7‐trihydroxyflavone) is one of the most …
children and adolescents. Apigenin (4′, 5, 7‐trihydroxyflavone) is one of the most …
CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1‑mediated Warburg effect
W Yang, Y Wang, C Tao, Y Li, S Cao… - Oncology …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most prevalent gastrointestinal tumors worldwide, with
a high mortality rate. The lncRNA colorectal neoplasia differentially expressed (CRNDE) is …
a high mortality rate. The lncRNA colorectal neoplasia differentially expressed (CRNDE) is …
Updated understanding of the causes of cancer, and a new theoretical perspective of combinational cancer therapies, a hypothesis
C Muresanu, S Khalchitsky - DNA and Cell Biology, 2022 - liebertpub.com
We present an integrative understanding of cancer as a metabolic multifactorial, multistage
disease. We focus on underlying genetics–environmental interactions, evidenced by …
disease. We focus on underlying genetics–environmental interactions, evidenced by …
MicroRNAs and metabolism: revisiting the Warburg effect with emphasis on epigenetic background and clinical applications
Z Gaál - Biomolecules, 2021 - mdpi.com
Since the well-known hallmarks of cancer were described by Hanahan and Weinberg,
fundamental advances of molecular genomic technologies resulted in the discovery of novel …
fundamental advances of molecular genomic technologies resulted in the discovery of novel …
Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription
Y Zhang, H Song, M Li, P Lu - Clinical and Translational …, 2024 - Wiley Online Library
Heightened lactate production in cancer cells has been linked to various cellular
mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell …
mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell …
Ethanol exposure attenuates immune response in sepsis via sirtuin 2 expression
A Gandhirajan, S Roychowdhury… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Background Sepsis and septic shock kill over 270,000 patients per year in the United States.
Sepsis transitions from a hyper‐inflammatory to a hypo‐inflammatory phase. Alcohol …
Sepsis transitions from a hyper‐inflammatory to a hypo‐inflammatory phase. Alcohol …