Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Background The last decade witnessed the emergence of several therapeutic options for
patients with chronic lymphocytic leukemia (CLL) for first-line and relapsed settings. The vast …

Evidence for the existence of CLL-specific antigens recognized by the immune system can
be gathered from the observation that many patients display monoclonal or oligoclonal …

Gene profiling studies of patients with chronic lymphocytic leukemia (CLL) has revealed
increased expression of Ror1, a cell surface receptor tyrosine kinase. The aim of present …

The tumoral clone of Waldenström's macroglobulinemia (WM) shows a wide morphological
heterogeneity, which ranges from B lymphocytes (BL) to plasma cells (PC). By means of …

Eighteen relapsed patients with measurable indolent non-Hodgkin lymphoma (NHL) were
vaccinated with dendritic cells (DCs) loaded with killed autologous tumor cells. Six patients …

Fibromodulin (FMOD) is known as one of very important extracellular matrix small leucine-
rich proteoglycans. This small leucine-rich proteoglycan has critical roles in the extracellular …

Differentiation of muscle satellite cells (MSCs) involves interaction of the proteins present in
the extracellular matrix (ECM) with MSCs to regulate their activity, and therefore phenotype …

Proteoglycans consist of a protein core with one or more covalently attached
glycosaminoglycan (GAG) side chains and have multiple roles in the initiation and …