Chagas' disease

C Bern - New England Journal of Medicine, 2015 - Mass Medical Soc
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Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and slee** sickness

S Khare, AS Nagle, A Biggart, YH Lai, F Liang… - Nature, 2016 - nature.com
Chagas disease, leishmaniasis and slee** sickness affect 20 million people worldwide
and lead to more than 50,000 deaths annually. The diseases are caused by infection with …

Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled …

F Torrico, J Gascon, L Ortiz, C Alonso-Vega… - The Lancet Infectious …, 2018 - thelancet.com
Background Chagas disease is a major neglected vector-borne disease. In this study, we
investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole …

Current drug therapy and pharmaceutical challenges for Chagas disease

J Bermudez, C Davies, A Simonazzi, JP Real, S Palma - Acta tropica, 2016 - Elsevier
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

Worldwide control and management of Chagas disease in a new era of globalization: a close look at congenital Trypanosoma cruzi infection

A Abras, C Ballart, A Fernández-Arévalo… - Clinical microbiology …, 2022 - Am Soc Microbiol
Population movements have turned Chagas disease (CD) into a global public health
problem. Despite the successful implementation of subregional initiatives to control vectorial …

Chagas disease in Europe: a review for the internist in the globalized world

S Antinori, L Galimberti, R Bianco, R Grande… - European Journal of …, 2017 - Elsevier
Chagas disease (CD) or American trypanosomiasis identified in 1909 by Carlos Chagas,
has become over the last 40 years a global health concern due to the huge migration flows …

Clinical and pharmacological profile of benznidazole for treatment of Chagas disease

J Müller Kratz, F Garcia Bournissen… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Chagas disease (CD) is one of the most neglected public health problems in
the Americas, where< 1% of the estimated 6 million people with the infection have been …

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for …

A Rassi Jr, JA Marin, A Rassi - Memórias do Instituto Oswaldo Cruz, 2017 - SciELO Brasil
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic
Chagas disease, and is one of the leading causes of morbidity and death in Latin America …

Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

SS Santos, RV de Araújo, J Giarolla, O El Seoud… - International journal of …, 2020 - Elsevier
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …