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Immunobiology and pathogenesis of viral hepatitis
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …
Genetic diversity and evolution of hepatitis C virus–15 years on
P Simmonds - Journal of General Virology, 2004 - microbiologyresearch.org
In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …
its role as a major causative agent of human liver disease and its ability to persist in the face …
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
JJ Feld, JH Hoofnagle - Nature, 2005 - nature.com
Since the identification of the hepatitis C virus, great strides have been made in the
development of an antiviral therapy. As a crucial mediator of the innate antiviral immune …
development of an antiviral therapy. As a crucial mediator of the innate antiviral immune …
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I
Virus-responsive signaling pathways that induce alpha/beta interferon production and
engage intracellular immune defenses influence the outcome of many viral infections. The …
engage intracellular immune defenses influence the outcome of many viral infections. The …
Mechanisms of action of ribavirin against distinct viruses
The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in
vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral …
vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral …
Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection
Few hepatitis C virus (HCV) infections resolve spontaneously but those that do appear to
afford protective immunity. Second infections are usually shorter in duration and are less …
afford protective immunity. Second infections are usually shorter in duration and are less …
Adaptive immune responses in acute and chronic hepatitis C virus infection
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …
cause of human illness and death globally. Recent studies have yielded important insights …
Interferons α and λ inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
T Marcello, A Grakoui, G Barba–Spaeth, ES Machlin… - Gastroenterology, 2006 - Elsevier
Background & Aims: Hepatitis C virus (HCV) is a major cause of chronic liver disease,
cirrhosis, and hepatocellular carcinoma. Current therapy with pegylated interferon α (IFN-α) …
cirrhosis, and hepatocellular carcinoma. Current therapy with pegylated interferon α (IFN-α) …
Stealth and cunning: hepatitis B and hepatitis C viruses
SF Wieland, FV Chisari - Journal of virology, 2005 - journals.asm.org
The hepatitis B virus (HBV) and hepatitis C virus (HCV) are noncytopathic, hepatotropic
members of the hepadnavirus (HBV) and ffavivirus (HCV) families that cause acute and …
members of the hepadnavirus (HBV) and ffavivirus (HCV) families that cause acute and …
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling
Hepatitis C virus (HCV) is a major human pathogen that infects 170 million people. A
hallmark of HCV is its ability to establish persistent infections reflecting the evasion of host …
hallmark of HCV is its ability to establish persistent infections reflecting the evasion of host …