Immunobiology and pathogenesis of viral hepatitis

LG Guidotti, FV Chisari - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Genetic diversity and evolution of hepatitis C virus–15 years on

P Simmonds - Journal of General Virology, 2004 - microbiologyresearch.org
In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

Mechanism of action of interferon and ribavirin in treatment of hepatitis C

JJ Feld, JH Hoofnagle - Nature, 2005 - nature.com
Since the identification of the hepatitis C virus, great strides have been made in the
development of an antiviral therapy. As a crucial mediator of the innate antiviral immune …

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

R Sumpter Jr, YM Loo, E Foy, K Li… - Journal of …, 2005 - journals.asm.org
Virus-responsive signaling pathways that induce alpha/beta interferon production and
engage intracellular immune defenses influence the outcome of many viral infections. The …

Mechanisms of action of ribavirin against distinct viruses

JD Graci, CE Cameron - Reviews in medical virology, 2006 - Wiley Online Library
The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in
vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral …

Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection

NH Shoukry, A Grakoui, M Houghton… - Journal of Experimental …, 2003 - rupress.org
Few hepatitis C virus (HCV) infections resolve spontaneously but those that do appear to
afford protective immunity. Second infections are usually shorter in duration and are less …

Adaptive immune responses in acute and chronic hepatitis C virus infection

DG Bowen, CM Walker - Nature, 2005 - nature.com
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

Interferons α and λ inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics

T Marcello, A Grakoui, G Barba–Spaeth, ES Machlin… - Gastroenterology, 2006 - Elsevier
Background & Aims: Hepatitis C virus (HCV) is a major cause of chronic liver disease,
cirrhosis, and hepatocellular carcinoma. Current therapy with pegylated interferon α (IFN-α) …

Stealth and cunning: hepatitis B and hepatitis C viruses

SF Wieland, FV Chisari - Journal of virology, 2005 - journals.asm.org
The hepatitis B virus (HBV) and hepatitis C virus (HCV) are noncytopathic, hepatotropic
members of the hepadnavirus (HBV) and ffavivirus (HCV) families that cause acute and …

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

E Foy, K Li, R Sumpter Jr, YM Loo, CL Johnson… - Proceedings of the …, 2005 - pnas.org
Hepatitis C virus (HCV) is a major human pathogen that infects 170 million people. A
hallmark of HCV is its ability to establish persistent infections reflecting the evasion of host …