The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases
that have inflammation as a common underlying cause. sEH limits tissue levels of …

Wound healing is an evolutionarily conserved process that is essential for species survival.
Wound healing involves a series of biochemical and cellular events that are tightly …

Aims Endothelial‐derived epoxyeicosatrienoic acids may regulate vascular tone and are
metabolized by soluble epoxide hydrolase enzymes (sEH). GSK2256294 is a potent and …

Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …

Eicosanoids are lipid signaling molecules derived from the oxidation of ω-6 fatty acids,
usually arachidonic acid. There are three major pathways, including the cyclooxygenase …

Angiogenesis, the growth of new blood vessels, plays a critical role in tissue repair and
regeneration, as well as in cancer. A paradigm shift is emerging in our understanding of the …

The “modern western” diet (MWD) has increased the onset and progression of chronic
human diseases as qualitatively and quantitatively maladaptive dietary components give …

A novel genus of pro-resolving lipid mediators endogenously generated from omega-3
polyunsaturated fatty acids has been identified in exudates obtained during the resolution …