Glutamate receptors, neurotoxicity and neurodegeneration
A Lau, M Tymianski - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …
Inhibition of caspase 3 and caspase 9 mediated apoptosis: a multimodal therapeutic target in traumatic brain injury
Traumatic brain injury (TBI) is one of the significant causes of death and morbidity, and it is
hence a focus of translational research. Apoptosis plays an essential part in the …
hence a focus of translational research. Apoptosis plays an essential part in the …
Traumatic brain injury: can the consequences be stopped?
E Park, JD Bell, AJ Baker - Cmaj, 2008 - Can Med Assoc
Traumatic brain injury is a leading cause of morbidity and death in both industrialized and
develo** countries. To date, there is no targeted pharmacological treatment that effectively …
develo** countries. To date, there is no targeted pharmacological treatment that effectively …
In vitro models of traumatic brain injury
In vitro models of traumatic brain injury (TBI) are hel** elucidate the pathobiological
mechanisms responsible for dysfunction and delayed cell death after mechanical stimulation …
mechanisms responsible for dysfunction and delayed cell death after mechanical stimulation …
Neurons respond directly to mechanical deformation with pannexin‐mediated ATP release and autostimulation of P2X7 receptors
Key points• Neurons can be damaged when tissues are stretched or swollen; while
astrocytes can contribute to this process, the mechanosensitive response from neurons is …
astrocytes can contribute to this process, the mechanosensitive response from neurons is …
PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury
Traumatic brain injury (TBI) causes neuronal cell death as well as microglial activation and
related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP …
related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP …
Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways
X Ma, C Dang, H Kang, Z Dai, S Lin, H Guan… - International …, 2015 - Elsevier
The nephrotoxicity induced by cisplatin (DDP) severely limits the clinical efficacy of this
widely used anticancer agent. The observed nephrotoxicity may be the result of DDP …
widely used anticancer agent. The observed nephrotoxicity may be the result of DDP …
Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury
Y Deng, BM Thompson, X Gao, ED Hall - Experimental neurology, 2007 - Elsevier
We assessed the temporal and spatial characteristics of PN-induced oxidative damage and
its relationship to calpain-mediated cytoskeletal degradation and neurodegeneration in a …
its relationship to calpain-mediated cytoskeletal degradation and neurodegeneration in a …
Cellular mechanisms of peroxynitrite-induced neuronal death
K Ramdial, MC Franco, AG Estevez - Brain research bulletin, 2017 - Elsevier
Peroxynitrite (ONOO−) is a strong biological oxidant formed by the diffusion-limited reaction
of nitric oxide (NO−) and superoxide anion (O 2 radical dot−). It has long been theorized that …
of nitric oxide (NO−) and superoxide anion (O 2 radical dot−). It has long been theorized that …