Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

Regulated secretion of stored secretory products is important in many cell types. In contrast
to professional secretory cells, which store their secretory products in specialized secretory …

The high transmissibility of SARS-CoV-2 is related to abundant replication in the upper
airways, which is not observed for the other highly pathogenic coronaviruses SARS-CoV …

Atherosclerosis is an inflammatory disease characterized by extensive remodeling of the
extracellular matrix architecture of the arterial wall. Although matrix metalloproteinases and …

The major endoproteolytic processing enzymes of the secretory pathway are the subtilisin-
like proprotein convertases (SPCs). Furin (SPC1) has emerged as one of the major …

▪ Abstract There has recently been considerable progress in understanding the regulation of
clathrin-coated vesicle (CCV) formation and function. These advances are due to the …

Insulin controls glucose homeostasis by regulating glucose use in peripheral tissues, and its
own production and secretion in pancreatic β cells,,. These responses are largely mediated …

Secretory granules are specialized intracellular organelles that serve as a storage pool for
selected secretory products. The exocytosis of secretory granules is markedly amplified …

Many cellular processes, including embryogenesis (1–4), gene expression (5), cell cycle (6),
programmed cell death (7), intracellular protein targeting (8) and endocrine/neural functions …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …