The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Acute kidney injury occurs with kidney transplantation and too frequently progresses to the
clinical diagnosis of delayed graft function (DGF). Poor kidney function in the first week of …

Acute kidney injury is a common complication of rhabdomyolysis. A better understanding of
this syndrome may be useful to identify novel therapeutic targets because there is no …

Uropathogenic Escherichia coli (UPEC) is a causative agent in the vast majority of urinary
tract infections (UTIs), including cystitis and pyelonephritis, and infectious complications …

Lysosomal storage diseases are usually considered to be pathologies in which the passive
deposition of unwanted materials leads to functional changes in lysosomes. Lysosomal …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of
TLRs by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of …

Salidroside (Sal) is an active ingredient that is isolated from Rhodiola rosea, which has been
reported to have anti-inflammatory activities and a renal protective effect. However, the role …

Gasdermin D (GSDMD) has been proven to be a key protein in the activation of pyroptosis.
Pyroptosis of renal tubular epithelial cells contributes to the progression of tubular injury in …