Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

A Malek-Khatabi, MS Razavi, A Abdollahi… - Biomaterials …, 2023 - pubs.rsc.org
Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein
and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to …

Long-acting vaccine delivery systems

P Walvekar, P Kumar, YE Choonara - Advanced Drug Delivery Reviews, 2023 - Elsevier
Bolus vaccines are often administered multiple times due to rapid clearance and reduced
transportation to draining lymph nodes resulting in inadequate activation of T and B …

Polymeric and composite-based microneedles in drug delivery: regenerative medicine, microbial infection therapy, and cancer treatment

FZ Amourizi, AZ Malek-Khatabi… - Materials Chemistry …, 2023 - mch.du.ac.ir
Microneedles (MNs) are microscopic, needle-like structures employed in drug delivery
through the skin. They are non-invasive and cause minimal to no pain at the site of insertion …

Botulinum toxin A dissolving microneedles for hyperhidrosis treatment: design, formulation and in vivo evaluation

A Malek-Khatabi, M Rad-Malekshahi, M Shafiei… - Biomaterials …, 2023 - pubs.rsc.org
Multiple periodic injections of botulinum toxin A (BTX-A) are the standard treatment of
hyperhidrosis which causes excessive sweating. However, BTX-A injections can create …

Nanocarrier vaccines for respiratory infections

Y Jiang, L Lei, M Zhao, Y Tian, Y Huang… - Trends in Molecular …, 2025 - cell.com
Respiratory infections continue to pose a major global health challenge, leading to high
morbidity and mortality. Effective vaccines are crucial for prevention of these, and …

A stimulus responsive microneedle-based drug delivery system for cancer therapy

H Tang, X Cheng, L Liang, BZ Chen, C Liu… - Biomaterials …, 2024 - pubs.rsc.org
The intricate nature of the tumor microenvironment (TME) results in the inefficient delivery of
anticancer drugs within tumor tissues, significantly compromising the therapeutic effect of …

PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach

R Jamaledin, R Sartorius, C Di Natale, V Onesto… - Journal of Nanostructure …, 2024 - Springer
Bacteriophages have attracted great attention in the bioengineering field in diverse research
areas from tissue engineering to therapeutic and clinical applications. Recombinant …

Modeling the kinetics of lymph node retention and exposure of a cargo protein delivered by biotin-functionalized nanoparticles

PR Hartmeier, JL Kosanovich, KY Velankar… - Acta biomaterialia, 2023 - Elsevier
Generation of protective immunity through vaccination arises from the adaptive immune
response developed primarily in the lymph nodes drained from the immunization site …

Current research on bacterial diseases in eel: An immunological perspective

T Qi, S Wei, Z Li, L Ribas, Q Cao - Aquaculture, 2024 - Elsevier
Global eel production has dramatically increased over the last 30 years due to the
expansion of eel farming to meet rising human food demands. More than 45 countries …

3D printing of drug delivery systems enhanced with micro/nano-technology

H Zhu, H Kuang, X Huang, X Li, R Zhao… - Advanced Drug Delivery …, 2024 - Elsevier
Drug delivery systems (DDSs) are increasingly important in ensuring drug safety and
enhancing therapeutic efficacy. Micro/nano-technology has been utilized to develop DDSs …