Sifting through the surfeit of neuroinflammation tracers
The first phase of molecular brain imaging of microglial activation in neuroinflammatory
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
Quantitative imaging of protein targets in the human brain with PET
PET imaging of proteins in the human brain with high affinity radiolabelled molecules has a
history stretching back over 30 years. During this period the portfolio of protein targets that …
history stretching back over 30 years. During this period the portfolio of protein targets that …
Prefrontal and striatal dopamine release are inversely correlated in schizophrenia
WG Frankle, M Himes, NS Mason, CA Mathis… - Biological …, 2022 - Elsevier
Background The dopamine (DA) hypothesis postulates hyperactivity of subcortical DA
transmission and hypoactivity of cortical DA in schizophrenia (SCH). Positron emission …
transmission and hypoactivity of cortical DA in schizophrenia (SCH). Positron emission …
Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
P Plavén-Sigray, P Ikonen Victorsson, A Santillo… - Molecular …, 2022 - nature.com
Pharmacological and genetic evidence support a role for an involvement of the dopamine
D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging …
D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging …
The simplified reference tissue model: model assumption violations and their impact on binding potential
CA Salinas, GE Searle… - Journal of Cerebral Blood …, 2015 - journals.sagepub.com
Reference tissue models have gained significant traction over the last two decades as the
methods of choice for the quantification of brain positron emission tomography data because …
methods of choice for the quantification of brain positron emission tomography data because …
Impaired Prefrontal Cortical Dopamine Release in Schizophrenia During a Cognitive Task: A [11C]FLB 457 Positron Emission Tomography Study
Evidence from several lines of research suggests decreased dopamine release in the
prefrontal cortex as the neurochemical correlates of cognitive deficits in schizophrenia …
prefrontal cortex as the neurochemical correlates of cognitive deficits in schizophrenia …
Quantitation of dynamic total-body PET imaging: recent developments and future perspectives
F Gu, Q Wu - European Journal of Nuclear Medicine and Molecular …, 2023 - Springer
Background Positron emission tomography (PET) scanning is an important diagnostic
imaging technique used in disease diagnosis, therapy planning, treatment monitoring, and …
imaging technique used in disease diagnosis, therapy planning, treatment monitoring, and …
In vivo quantification of regional dopamine‐D3 receptor binding potential of (+)‐PHNO: Studies in non‐human primates and transgenic mice
EA Rabiner, M Slifstein, J Nobrega, C Plisson… - Synapse, 2009 - Wiley Online Library
Examination of dopamine‐D3 (D3) receptors with positron emission tomography (PET) have
been hampered in the past by the lack of a PET ligand with sufficient selectivity for D3 over …
been hampered in the past by the lack of a PET ligand with sufficient selectivity for D3 over …
Reference Region Modeling Approaches for Amphetamine Challenge Studies with [11C]FLB 457 and PET
CM Sandiego, JD Gallezot, K Lim… - Journal of Cerebral …, 2015 - journals.sagepub.com
Detecting fluctuations in synaptic dopamine levels in extrastriatal brain regions with [11C]
FLB 457 and positron emission tomography (PET) is a valuable tool for studying …
FLB 457 and positron emission tomography (PET) is a valuable tool for studying …
Positron emission tomography imaging of amphetamine‐induced dopamine release in the human cortex: A comparative evaluation of the high affinity dopamine D2/3 …
R Narendran, WG Frankle, NS Mason, EA Rabiner… - Synapse, 2009 - Wiley Online Library
The use of PET and SPECT endogenous competition binding techniques has contributed to
the understanding of the role of dopamine in several neuropsychiatric disorders. An …
the understanding of the role of dopamine in several neuropsychiatric disorders. An …