Neuropathic pain (NP) refers to pain caused by primary or secondary damage or dysfunction
of the peripheral or central nervous system, which seriously affects the physical and mental …

In the two decades since the discovery of the nociceptin opioid receptor (NOP) and its
ligand, nociceptin/orphaninFQ (N/OFQ), steady progress has been achieved in …

ABSTARCT Cebranopadol (trans-6′-fluoro-4′, 9′-dihydro-N, N-dimethyl-4-phenyl-spiro
[cyclohexane-1, 1′(3′ H)-pyrano [3, 4-b] indol]-4-amine) is a novel analgesic …

Neuropathic pain (NeuP) is a syndrome that results from damaged nerves and/or aberrant
regeneration. Common etiologies of neuropathy include chronic illnesses and medication …

Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and
opioid receptors, marked differences in endogenous ligand selectivity, signal transduction …

Opioids are broad spectrum analgesics that may be beneficial to alleviate the intense
perception of algesia in patients suffering with pain. They have been one of the most …

Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …

The advance of functional genomics revealed the superfamily of G-protein coupled
receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Opioids are characterised as classical (mu, delta, and kappa) along with the non-classical
nociceptin/orphanin FQ (N/OFQ) receptor or NOP. Targeting NOP has therapeutic …