Challenges and opportunities for develo** more generalizable polygenic risk scores
Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …
diseases by aggregating information across multiple genetic variants identified from genome …
Genetic prediction of complex traits with polygenic scores: a statistical review
Accurate genetic prediction of complex traits can facilitate disease screening, improve early
intervention, and aid in the development of personalized medicine. Genetic prediction of …
intervention, and aid in the development of personalized medicine. Genetic prediction of …
Genome-wide association testing beyond SNPs
Decades of genetic association testing in human cohorts have provided important insights
into the genetic architecture and biological underpinnings of complex traits and diseases …
into the genetic architecture and biological underpinnings of complex traits and diseases …
[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …
data can shed light on the molecular mechanisms underlying the structural and functional …
How to estimate heritability: A guide for genetic epidemiologists
Traditionally, heritability has been estimated using family-based methods such as twin
studies. Advancements in molecular genomics have facilitated the development of methods …
studies. Advancements in molecular genomics have facilitated the development of methods …
Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling
Mendelian randomization (MR) is a common tool for identifying causal risk factors
underlying diseases. Here, we present a method, MR with automated instrument …
underlying diseases. Here, we present a method, MR with automated instrument …
Heritability estimation approaches utilizing genome‐wide data
Prior to the development of genome‐wide arrays and whole genome sequencing
technologies, heritability estimation mainly relied on the study of related individuals. Over …
technologies, heritability estimation mainly relied on the study of related individuals. Over …
Accurate and efficient estimation of local heritability using summary statistics and the linkage disequilibrium matrix
Existing SNP-heritability estimators that leverage summary statistics from genome-wide
association studies (GWAS) are much less efficient (ie, have larger standard errors) than the …
association studies (GWAS) are much less efficient (ie, have larger standard errors) than the …
[HTML][HTML] Comparison of multiple imputation algorithms and verification using whole-genome sequencing in the CMUH genetic biobank
TY Liu, CF Lin, HT Wu, YL Wu, YC Chen, CC Liao… - Biomedicine, 2021 - ncbi.nlm.nih.gov
A genome-wide association study (GWAS) can be conducted to systematically analyze the
contributions of genetic factors to a wide variety of complex diseases. Nevertheless, existing …
contributions of genetic factors to a wide variety of complex diseases. Nevertheless, existing …
“Fast” women? The effects of childhood environments on women's developmental timing, mating strategies, and reproductive outcomes
The fast-slow paradigm of life history theory has been a popular approach to individual
differences in the evolutionary behavioral sciences. Currently, however, the fast-slow …
differences in the evolutionary behavioral sciences. Currently, however, the fast-slow …