Immune regulation by parasites is a global concept that includes suppression, diversion,
and conversion of the host immune response to the benefit of the pathogen. While many …

Helminth parasites are complex metazoans that belong to different taxonomic families but
that collectively share the capacity to downregulate the host immune response directed …

The scid mutation was backcrossed ten generations onto the NOD/Lt strain background,
resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive …

There is increasing interest in helminth parasite modulation of the immune system, both from
the fundamental perspective of the “arms race” between host and parasite, and equally …

Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in
affluent countries, the deliberate infection of patients with worms is being explored as a …

The protective efficacy of BCG vaccination against pulmonary tuberculosis (TB) is highly
variable in different populations. The reason remains to be elucidated. This study aims to …

Parasitic helminths release molecules into their environment, which are generally referred to
as excretory-secretory products or ES. ES derived from a wide range of nematodes …

Human filarial parasites cause chronic infection associated with long-term down-regulation
of the host's immune response. We show here that CD4+ T cell regulation is the main …

Deriving from Pratt's Fundamentals of Chemotherapy (OUP, 1973), Chemotherapy of
Infection (OUP, 1977), and The Antimicrobial Drugs (OUP, 1986), this superb text surveys …

The immunological mechanisms involved in maintenance of an asymptomatic microfilaremic
state (MF) in patients with lymphatic filariasis remain undefined. MF patients have impaired …