Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …

AT-rich interaction domain protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex
subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Diabetic wound healing (DWH) represents a major complication of diabetes where
inflammation is a key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS) …

Pediatric high-grade gliomas (pHGG) are devastating and incurable brain tumors with
recurrent mutations in histone H3. 3. These mutations promote oncogenesis by …

Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by
clonal mutations in histone genes. They often harbor a range of additional genetic …

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis. The
number of cases increased by 2.26 million in 2020, making it the most commonly diagnosed …

Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and
the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME …