Abstract Purpose Cancer stem cells (CSCs) are highly tumorigenic cell types that reside
within specific areas of tumor microenvironment (TME), and are endowed with self-renewal …

Hypoxia is an important feature of most solid tumors, conferring resistance to radiation and
many forms of chemotherapy. However, it is possible to exploit the presence of tumor …

Cancer stem cells (CSCs) are responsible for tumor progression, recurrence, and drug
resistance. To identify genetic vulnerabilities of colon cancer, we performed targeted …

Background Glioblastoma multiforme and other solid malignancies are heterogeneous,
containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known …

Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery
since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first …

The formation of hypoxic microenvironments within solid tumors is known to contribute to
radiation resistance, chemotherapy resistance, immune suppression, increased metastasis …

Cancer cells rewire metabolic processes to adapt to the nutrient-and oxygen-deprived
tumour microenvironment, thereby promoting their proliferation and metastasis. Previous …

Hypoxia is prominent in solid tumors and a recognized driver of malignancy. Thus far,
targeting tumor hypoxia has remained unsuccessful. Myo-inositol trispyrophosphate (ITPP) …

Background Immune checkpoint inhibitor therapy has revolutionized the clinical
management of a diverse range of cancer types, including advanced cutaneous melanoma …

Simple Summary Hypoxia is a negative prognostic factor known to be closely associated
with tumor progression and metastasis. However, existing animal models with the ability to …