One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

Introduction: Galectin-3 (Gal-3), a lectin with preference for β-galactoside-containing
carbohydrates, is a structurally unique member of the galectin family. It is ubiquitously …

Discovery of glycan‐competitive galectin‐3‐binding compounds that attenuate lung fibrosis
in a murine model and that block intracellular galectin‐3 accumulation at damaged vesicles …

The protein K-Ras functions as a molecular switch in signaling pathways regulating cell
growth. In the human mitogen-activated protein kinase (MAPK) pathway, which is implicated …

Human galectins are promising targets for cancer immunotherapeutic and fibrotic disease-
related drugs. We report herein the binding interactions of three thio-digalactosides (TDGs) …

Synthesis of doubly 3-O-coumarylmethyl-substituted thiodigalactosides from bis-3-O-
propargyl-thiodigalactoside resulted in highly selective and high affinity galectin-3 inhibitors …

Galectin-3 (Gal-3), a member of the β-galactoside-binding lectin family, is a tumor biomarker
and involved in tumor angiogenesis and metastasis. Gal-3 is therefore considered as a …

Galectins have essential roles in pathological states including cancer, inflammation,
angiogenesis and microbial infections. Endogenous receptors include members of the lacto …

The medically important drug target galectin-3 binds galactose-containing moieties on
glycoproteins through an intricate pattern of hydrogen bonds to a largely polar surface …

Although several approaches have been used to evaluate binding of carbohydrates to
lectins, results are not always comparable, especially with larger polysaccharides. Here, we …