Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial …
Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …
Homocysteine and age-associated disorders
There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …
White matter hyperintensities are a core feature of Alzheimer's disease: evidence from the dominantly inherited Alzheimer network
Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐
weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel …
weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel …
Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods
Cerebral blood flow (CBF) and cerebral autoregulation (CA) are critically important to
maintain proper brain perfusion and supply the brain with the necessary oxygen and energy …
maintain proper brain perfusion and supply the brain with the necessary oxygen and energy …
Higher aortic stiffness is related to lower cerebral blood flow and preserved cerebrovascular reactivity in older adults
Background: Mechanisms underlying the association between age-related arterial stiffening
and poor brain health remain elusive. Cerebral blood flow (CBF) homeostasis may be …
and poor brain health remain elusive. Cerebral blood flow (CBF) homeostasis may be …
Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the …
L Calderón-Garcidueñas, R Reynoso-Robles… - Environmental …, 2016 - Elsevier
Millions of urban children are chronically exposed to high concentrations of air pollutants, ie,
fine particulate matter (PM 2.5) and ozone, associated with increased risk for Alzheimer's …
fine particulate matter (PM 2.5) and ozone, associated with increased risk for Alzheimer's …
Reduced regional cerebral blood flow relates to poorer cognition in older adults with type 2 diabetes
Type 2 diabetes mellitus (T2DM) increases risk for dementia, including Alzheimer's disease
(AD). Many previous studies of brain changes underlying cognitive impairment in T2DM …
(AD). Many previous studies of brain changes underlying cognitive impairment in T2DM …
Associations between amyloid β and white matter hyperintensities: a systematic review
Introduction This systematic review synthesizes current evidence for associations between
cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white …
cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white …
Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease
Executive dysfunction is the most important predictor for loss of independence in dementia.
As executive function involves the coordination of distributed cerebral functions, executive …
As executive function involves the coordination of distributed cerebral functions, executive …
Blood will out: vascular contributions to Alzheimer's disease
S Strickland - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
The fundamental pathology in Alzheimer's disease (AD) is neuronal dysfunction leading to
cognitive impairment. The amyloid-β peptide (Aβ), derived from amyloid precursor protein, is …
cognitive impairment. The amyloid-β peptide (Aβ), derived from amyloid precursor protein, is …