Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Molecular target inhibitors have been regularly approved by Food and Drug Administration
(FDA) for tumor treatment, and most of them intervene in tumor cell proliferation and …

The mitogen-activated protein kinase (MAPK) family is an important bridge in the
transduction of extracellular and intracellular signals in different responses at the cellular …

Gliomas are the most aggressive primary intracranial malignancies with poor overall
survival. ITGA5 is one member of the integrin adhesion molecule family and is implicated in …

Thermal proteome profiling (TPP) provides a powerful approach to studying proteome-wide
interactions of small therapeutic molecules and their target and off-target proteins …

Paeoniflorin is a water-soluble monoterpenoid glycoside that can be derived from multiple
herbaceous plants, such as Radix Paeoniae Rubra, Radix Paeoniae Alba, Paeonia …

SOX transcription factors are critical regulators of development, homeostasis and disease
progression and their dysregulation is a common finding in various cancers. SOX9 belongs …

A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-
stranded regulatory RNAs, are dysregulated in a different variety of human cancers …

Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine
triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells …

The aim of the study was to investigated the mechanism of Strychnos nux-vomica L.(Semen
Strychni, SS) against papillary carcinoma thyroid (PTC) by combined of network …