The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

Clustered imprinted genes are regulated by differentially methylated imprinting control
regions (ICRs) that affect gene activity and repression in cis over a large region. Although a …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …

Imprinted genes play crucial roles in mammalian development and disruption of their
expression is associated with many human disorders including tumourigenesis; yet, the …

Angelman syndrome is a devastating neurogenetic disorder for which there is currently no
effective treatment. It is caused by mutations or epimutations affecting the expression or …

Genomic imprinting refers to an epigenetic mark that distinguishes parental alleles and
results in a monoallelic, parental-specific expression pattern in mammals. Few phenomena …

Alternative splicing (AS) plays a major role in the generation of proteomic diversity and in
gene regulation. However, the role of the basal splicing machinery in regulating AS remains …

Background We present the genome sequence of the tammar wallaby, Macropus eugenii,
which is a member of the kangaroo family and the first representative of the iconic hop** …

Genomic imprinting is widespread in eutherian mammals. Marsupial mammals also have
genomic imprinting, but in fewer loci. It has long been thought that genomic imprinting is …

Comparisons between eutherians and marsupials suggest limited conservation of the
molecular mechanisms that control genomic imprinting in mammals. We have studied the …