Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …

The incidence and prevalence of chronic kidney disease (CKD), with diabetes and
hypertension accounting for the majority of cases, is on the rise, with up to 160 million …

Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Diabetic nephropathy is the major cause of end‐stage renal failure throughout the world in
both developed and develo** countries. Diabetes affects all cell types of the kidney …

In the past decade, our understanding of the role of podocytes in the function of the
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …