Aggregation-induced emission (AIE), life and health

H Wang, Q Li, P Alam, H Bai, V Bhalla, MR Bryce… - ACS …, 2023 - ACS Publications
Light has profoundly impacted modern medicine and healthcare, with numerous
luminescent agents and imaging techniques currently being used to assess health and treat …

Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers

J An, S Tang, G Hong, W Chen, M Chen, J Song… - Nature …, 2022 - nature.com
The most common working mechanism of photodynamic therapy is based on high-toxicity
singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on …

Aggregation‐induced emission: recent advances in materials and biomedical applications

X Cai, B Liu - Angewandte Chemie International Edition, 2020 - Wiley Online Library
The concept of aggregation‐induced emission (AIE) has opened new opportunities in many
research fields. Motivated by the unique feature of AIE fluorogens (AIEgens), during the past …

AIE-active luminogens as highly efficient free-radical ROS photogenerator for image-guided photodynamic therapy

Z Liu, Q Wang, W Qiu, Y Lyu, Z Zhu, X Zhao… - Chemical Science, 2022 - pubs.rsc.org
Image-guided photodynamic therapy (PDT) can realize highly precise and effective therapy
via the integration of imaging and therapy, and has created high requirements for …

Flexible modulation of cellular activities with cationic photosensitizers: insights of alkyl chain length on reactive oxygen species antimicrobial mechanisms

L Zheng, Y Zhu, Y Sun, S **a, S Duan, B Yu… - Advanced …, 2023 - Wiley Online Library
Cationic photosensitizers have good binding ability with negatively charged bacteria and
fungi, exhibiting broad applications potential in antimicrobial photodynamic therapy (aPDT) …

Activation of pyroptosis by membrane‐anchoring AIE photosensitizer design: new prospect for photodynamic cancer cell ablation

M Wu, X Liu, H Chen, Y Duan, J Liu, Y Pan… - Angewandte …, 2021 - Wiley Online Library
Pyroptosis as a lytic and inflammatory form of cell death is a powerful tool to fight against
cancer. However, pyroptosis is usually activated by chemotherapeutic drugs, which limits its …

Engineered bacteria labeled with iridium (III) photosensitizers for enhanced photodynamic immunotherapy of solid tumors

W Lin, Y Liu, J Wang, Z Zhao, K Lu, H Meng… - Angewandte …, 2023 - Wiley Online Library
Despite metal‐based photosensitizers showing great potential in photodynamic therapy for
tumor treatment, the application of the photosensitizers is intrinsically limited by their poor …

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Z Meng, H Xue, T Wang, B Chen, X Dong… - Journal of …, 2022 - Springer
Cancer remains a serious threat to human health owing to the lack of effective treatments.
Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment …

Antimicrobial photodynamic therapy: Latest developments with a focus on combinatory strategies

R Youf, M Müller, A Balasini, F Thétiot, M Müller… - Pharmaceutics, 2021 - mdpi.com
Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern
therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the …