Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing
the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which …

Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell
carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form …

Research on GPR34, which was discovered in 1999 as an orphan G protein-coupled
receptor of the rhodopsin-like class, disclosed its physiologic relevance only piece by piece …

Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney.
New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The …

Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively
characterized, frequently involving inactivation of the von Hippel–Lindau (VHL) tumor …

Clear cell renal cell carcinoma (ccRCC) has a poor prognosis despite novel biological
targeted therapies. Tumor aggressiveness and poor survival may correlate with tumor grade …

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell
carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and …

Alcohol misuse is common in many societies worldwide and is associated with extensive
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related …

Comprehensive transcriptome studies of cancers often rely on corresponding normal tissue
samples to serve as a transcriptional reference. In this study, we performed in-depth …

Extensive research has revealed the pivotal role of kinesin family member 20A (KIF20A) in
cancer. However, its latent involvement in renal clear cell carcinoma (ccRCC) still remains …