Systems biology of cancer metastasis

Y Suhail, MP Cain, K Vanaja, PA Kurywchak… - Cell systems, 2019 - cell.com
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlap** processes, as successfully metastasizing cells assume …

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: a new look at hallmarks of breast cancer

R Abdollahzadeh, A Daraei, Y Mansoori… - Journal of cellular …, 2019 - Wiley Online Library
Breast cancer (BC) is the most frequently occurring malignancy in women worldwide.
Despite the substantial advancement in understanding the molecular mechanisms and …

[HTML][HTML] RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics

MG Best, N Sol, I Kooi, J Tannous, BA Westerman… - Cancer cell, 2015 - cell.com
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and
local responses to tumor growth, thereby altering their RNA profile. We determined the …

DNA methylation markers for diagnosis and prognosis of common cancers

X Hao, H Luo, M Krawczyk, W Wei, W Wang… - Proceedings of the …, 2017 - pnas.org
The ability to identify a specific cancer using minimally invasive biopsy holds great promise
for improving the diagnosis, treatment selection, and prediction of prognosis in cancer …

Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins

Z Ji, R Song, A Regev, K Struhl - elife, 2015 - elifesciences.org
Using a new bioinformatic method to analyze ribosome profiling data, we show that 40% of
lncRNAs and pseudogene RNAs expressed in human cells are translated. In addition,~ 35 …

[PDF][PDF] OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs

J Anaya - PeerJ Computer Science, 2016 - peerj.com
OncoLnc is a tool for interactively exploring survival correlations, and for downloading
clinical data coupled to expression data for mRNAs, miRNAs, or long noncoding RNAs …

TANRIC: an interactive open platform to explore the function of lncRNAs in cancer

J Li, L Han, P Roebuck, L Diao, L Liu, Y Yuan… - Cancer …, 2015 - aacrjournals.org
Long noncoding RNAs (lncRNA) have emerged as essential players in cancer biology.
Using recent large-scale RNA-seq datasets, especially those from The Cancer Genome …

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

A Lin, C Li, Z **ng, Q Hu, K Liang, L Han, C Wang… - Nature cell …, 2016 - nature.com
Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert
their functions in many biological processes, their potential involvement in cytoplasmic …

The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy

Y Ye, Y **ang, FM Ozguc, Y Kim, CJ Liu, PK Park, Q Hu… - Cell systems, 2018 - cell.com
Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …

CT-based radiomics analysis of different machine learning models for differentiating benign and malignant parotid tumors

Y Zheng, D Zhou, H Liu, M Wen - European radiology, 2022 - Springer
Objectives This study aimed to explore and validate the value of different radiomics models
for differentiating benign and malignant parotid tumors preoperatively. Methods This study …