Congenital hypothyroidism (CH) may be primary, due to a defect affecting the thyroid gland
itself, or central, due to impaired thyroid-stimulating hormone (TSH)-mediated stimulation of …

Although newborn screening has virtually eradicated mental retardation due to congenital
hypothyroidism in parts of the world, new information continues to accumulate and new …

Background/Aims: Over the years a rise in the incidence of congenital hypothyroidism (CH)
has been described worldwide. The aim of our study was to investigate trends in the …

Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases, for which
the underlying mechanisms remain unknown; it is often accompanied by anemia and …

Background Thyroid hormones exert critical roles throughout the body and play an important
and permissive role in neuroendocrine, neurological, and neuromuscular function. Methods …

The proper organized expression of specific genes in time and space is responsible for the
organogenesis of the central nervous system including the cerebellum. The epigenetic …

Perinatal hypothyroidism impairs cerebellar organogenesis and results in motor
coordination defects. The thyroid hormone receptor binds to corepressor complexes …

Hypothyroidism is a condition in which the serum levels of thyroid hormones are below that
necessary to carry out physiological functions in the body. Hypothyroidism is related to …

Thyroid hormone is essential for normal fetal brain development in utero and for the first 2
years of life. The develo** fetus is initially reliant upon maternal thyroid hormones that …

Objectives Postnatal thyroid dysfunction is common in preterm infants but the relationship
between mild dysfunction and neurodevelopment is unclear. Our aim is to describe the …