Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have
consistently shown that creatine supplementation increases intramuscular creatine …

While the vast majority of research involving creatine supplementation has focused on
skeletal muscle, there is a small body of accumulating research that has focused on creatine …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

Although creatine has been mostly studied as an ergogenic aid for exercise, training, and
sport, several health and potential therapeutic benefits have been reported. This is because …

There is emerging interest regarding the potential beneficial effects of creatine
supplementation on indices of brain health and function. Creatine supplementation can …

Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic
cells′ life. Up to the 1990s of the past century, ROS have been solely considered as toxic …

Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell,
creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption …

Multiple molecular, cellular, structural, and functional changes occur in the brain during
aging. Neural cells may respond to these changes adaptively, or they may succumb to …

Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving
greater attention because of its beneficial effects in a wide number of human degenerative …

There is an extensive and still growing body of the literature supporting the efficacy of
creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective …