Alternative antibiotics in dentistry: Antimicrobial peptides

A Griffith, A Mateen, K Markowitz, SR Singer, C Cugini… - Pharmaceutics, 2022 - mdpi.com
The rise of antibiotic resistant bacteria due to overuse and misuse of antibiotics in medicine
and dentistry is a growing concern. New approaches are needed to combat antibiotic …

Short cationic peptidomimetic antimicrobials

R Kuppusamy, M Willcox, DSC Black, N Kumar - Antibiotics, 2019 - mdpi.com
The rapid growth of antimicrobial resistance against several frontline antibiotics has
encouraged scientists worldwide to develop new alternatives with unique mechanisms of …

Candidalysin is a fungal peptide toxin critical for mucosal infection

DL Moyes, D Wilson, JP Richardson, S Mogavero… - Nature, 2016 - nature.com
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial
pathogens which disrupt epithelial barrier function, damage cells and activate or modulate …

Lipid vesicles in pulsed electric fields: fundamental principles of the membrane response and its biomedical applications

DL Perrier, L Rems, PE Boukany - Advances in colloid and interface …, 2017 - Elsevier
The present review focuses on the effects of pulsed electric fields on lipid vesicles ranging
from giant unilamellar vesicles (GUVs) to small unilamellar vesicles (SUVs), from both …

The use of tethered bilayer lipid membranes to identify the mechanisms of antimicrobial peptide interactions with lipid bilayers

A Alghalayini, A Garcia, T Berry, CG Cranfield - Antibiotics, 2019 - mdpi.com
This review identifies the ways in which tethered bilayer lipid membranes (tBLMs) can be
used for the identification of the actions of antimicrobials against lipid bilayers. Much of the …

Mechanistic evaluation of antimicrobial lipid interactions with tethered lipid bilayers by electrochemical impedance spectroscopy

SW Tan, WY Jeon, BK Yoon, JA Jackman - Sensors, 2022 - mdpi.com
There is extensive interest in develo** real-time biosensing strategies to characterize the
membrane-disruptive properties of antimicrobial lipids and surfactants. Currently used …

Kalata b1 and kalata b2 have a surfactant-like activity in phosphatidylethanolomine-containing lipid membranes

CG Cranfield, ST Henriques, B Martinac, P Duckworth… - Langmuir, 2017 - ACS Publications
Cyclotides are cyclic disulfide-rich peptides that are chemically and thermally stable and
possess pharmaceutical and insecticidal properties. The activities reported for cyclotides …

Role of transmembrane potential and defects on the permeabilization of lipid bilayers by alamethicin, an ion-channel-forming peptide

ZF Su, M Shodiev, JJ Leitch, F Abbasi, J Lipkowski - Langmuir, 2018 - ACS Publications
The insertion and ion-conducting channel properties of alamethicin reconstituted into a 1, 2-
di-O-phytanyl-sn-glycero-3-phosphocholine bilayer floating on the surface of a gold (111) …

Evidence of the Key Role of H3O+ in Phospholipid Membrane Morphology

CG Cranfield, T Berry, SA Holt, KR Hossain… - Langmuir, 2016 - ACS Publications
This study explains the importance of the phosphate moiety and H3O+ in controlling the
ionic flux through phospholipid membranes. We show that despite an increase in the H3O+ …

Electrode-supported biomimetic membranes: An electrochemical and surface science approach for characterizing biological cell membranes

ZF Su, JJ Leitch, J Lipkowski - Current Opinion in Electrochemistry, 2018 - Elsevier
Planar solid-supported lipid bilayers have been developed as simplified biological
membranes to model the physical properties of cell membrane processes. Lipid bilayer …