Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications

Y Li, Y Liu, XY Yu, Y Xu, X Pan, Y Sun… - … and Targeted Therapy, 2024 - nature.com
Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …

[HTML][HTML] Transient, nano-scale, liquid-like molecular assemblies coming of age

A Kusumi, TA Tsunoyama, KGN Suzuki… - Current Opinion in Cell …, 2024 - Elsevier
This review examines the dynamic mechanisms underlying cellular signaling,
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …

Demixing is a default process for biological condensates formed via phase separation

S Zhu, Z Shen, X Wu, W Han, B Jia, W Lu, M Zhang - Science, 2024 - science.org
Excitatory and inhibitory synapses do not overlap even when formed on one submicron-
sized dendritic protrusion. How excitatory and inhibitory postsynaptic cytomatrices or …

Phase Separation–Mediated Compartmentalization Underlies Synapse Formation and Plasticity

X Wu, Z Shen, M Zhang - Annual Review of Neuroscience, 2025 - annualreviews.org
The synapse is polarized and highly compartmentalized on both its pre-and postsynaptic
sides. The compartmentalization of synaptic vesicles, as well as vesicle releasing and …

Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

T Zhang, S Liu, O Durojaye, F **ong, Z Fang, T Ullah… - Cell Reports, 2024 - cell.com
FOXA1 serves as a crucial pioneer transcription factor during developmental processes and
plays a pivotal role as a mitotic bookmarking factor to perpetuate gene expression profiles …

Physiological and pathological effects of phase separation in the central nervous system

J Wang, H Zhu, R Tian, Q Zhang, H Zhang, J Hu… - Journal of Molecular …, 2024 - Springer
Phase separation, also known as biomolecule condensate, participates in physiological
processes such as transcriptional regulation, signal transduction, gene expression, and …

Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates

GA Pérez, RV Pappu, D Milovanovic - Trends in cell biology, 2024 - cell.com
Can the fusion/fission of biomolecular condensates be regulated in cells? In a recent study,
Wu et al. show that phosphorylation of a key scaffold protein that drives condensates in …

Phase separation in the multi-compartment organization of synapses

S Zhu, Z Shen, X Wu, M Zhang - Current Opinion in Neurobiology, 2025 - Elsevier
A neuronal synapse is formed by juxtaposition of a transmitter releasing presynaptic bouton
of one neuron with a transmitter receiving postsynaptic compartment such as a spine …

Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes

X Zhang, X Chen, D Matúš, TC Südhof - Science, 2025 - science.org
Synapses are organized by trans-synaptic adhesion molecules that coordinate assembly of
pre-and postsynaptic specializations, which, in turn, are composed of scaffolding proteins …

Properties of Pickering Stabilized Associative Water‐In‐Water Emulsions Based on Ultra‐High Molecular Weight Polyacrylamides

RB Lira, A Plucinski, YB Ko, N Bayliss… - Advanced Materials …, 2024 - Wiley Online Library
Completely water‐based multicompartment systems have attracted a broad interest in recent
years, mainly due to their versatile features such as permeability. Here, the associative …