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Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications
Y Li, Y Liu, XY Yu, Y Xu, X Pan, Y Sun… - … and Targeted Therapy, 2024 - nature.com
Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …
cellular substructures involved in biological processes or pathways under physiological …
[HTML][HTML] Transient, nano-scale, liquid-like molecular assemblies coming of age
A Kusumi, TA Tsunoyama, KGN Suzuki… - Current Opinion in Cell …, 2024 - Elsevier
This review examines the dynamic mechanisms underlying cellular signaling,
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …
Demixing is a default process for biological condensates formed via phase separation
Excitatory and inhibitory synapses do not overlap even when formed on one submicron-
sized dendritic protrusion. How excitatory and inhibitory postsynaptic cytomatrices or …
sized dendritic protrusion. How excitatory and inhibitory postsynaptic cytomatrices or …
Phase Separation–Mediated Compartmentalization Underlies Synapse Formation and Plasticity
The synapse is polarized and highly compartmentalized on both its pre-and postsynaptic
sides. The compartmentalization of synaptic vesicles, as well as vesicle releasing and …
sides. The compartmentalization of synaptic vesicles, as well as vesicle releasing and …
Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation
T Zhang, S Liu, O Durojaye, F **ong, Z Fang, T Ullah… - Cell Reports, 2024 - cell.com
FOXA1 serves as a crucial pioneer transcription factor during developmental processes and
plays a pivotal role as a mitotic bookmarking factor to perpetuate gene expression profiles …
plays a pivotal role as a mitotic bookmarking factor to perpetuate gene expression profiles …
Physiological and pathological effects of phase separation in the central nervous system
Phase separation, also known as biomolecule condensate, participates in physiological
processes such as transcriptional regulation, signal transduction, gene expression, and …
processes such as transcriptional regulation, signal transduction, gene expression, and …
Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates
Can the fusion/fission of biomolecular condensates be regulated in cells? In a recent study,
Wu et al. show that phosphorylation of a key scaffold protein that drives condensates in …
Wu et al. show that phosphorylation of a key scaffold protein that drives condensates in …
Phase separation in the multi-compartment organization of synapses
A neuronal synapse is formed by juxtaposition of a transmitter releasing presynaptic bouton
of one neuron with a transmitter receiving postsynaptic compartment such as a spine …
of one neuron with a transmitter receiving postsynaptic compartment such as a spine …
Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes
X Zhang, X Chen, D Matúš, TC Südhof - Science, 2025 - science.org
Synapses are organized by trans-synaptic adhesion molecules that coordinate assembly of
pre-and postsynaptic specializations, which, in turn, are composed of scaffolding proteins …
pre-and postsynaptic specializations, which, in turn, are composed of scaffolding proteins …
Properties of Pickering Stabilized Associative Water‐In‐Water Emulsions Based on Ultra‐High Molecular Weight Polyacrylamides
RB Lira, A Plucinski, YB Ko, N Bayliss… - Advanced Materials …, 2024 - Wiley Online Library
Completely water‐based multicompartment systems have attracted a broad interest in recent
years, mainly due to their versatile features such as permeability. Here, the associative …
years, mainly due to their versatile features such as permeability. Here, the associative …