Smart contact lenses as wearable ophthalmic devices for disease monitoring and health management

H Seo, WG Chung, YW Kwon, S Kim, YM Hong… - Chemical …, 2023 - ACS Publications
The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …

[HTML][HTML] Immune responses to injury and their links to eye disease

MA Stepp, AS Menko - Translational Research, 2021 - Elsevier
The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

[HTML][HTML] Drug delivery to the posterior segment of the eye: Biopharmaceutic and pharmacokinetic considerations

R Varela-Fernández, V Díaz-Tomé… - Pharmaceutics, 2020 - mdpi.com
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases
(AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the …

[HTML][HTML] Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy—an overview on recent advances

S Jacob, AB Nair, J Shah, S Gupta, SHS Boddu… - Pharmaceutics, 2022 - mdpi.com
Due to complicated anatomical and physical properties, targeted drug delivery to ocular
tissues continues to be a key challenge for formulation scientists. Various attempts are …

[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery

EM Del Amo, AK Rimpelä, E Heikkinen, OK Kari… - Progress in retinal and …, 2017 - Elsevier
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

Design, clinical translation and immunological response of biomaterials in regenerative medicine

K Sadtler, A Singh, MT Wolf, X Wang… - Nature Reviews …, 2016 - nature.com
The field of regenerative medicine aims to replace tissues lost as a consequence of disease,
trauma or congenital abnormalities. Biomaterials serve as scaffolds for regenerative …

Biomarkers in diabetic retinopathy

AJ Jenkins, MV Joglekar, AA Hardikar… - The review of …, 2015 - pmc.ncbi.nlm.nih.gov
There is a global diabetes epidemic correlating with an increase in obesity. This coincidence
may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained …

Human vitreous in proliferative diabetic retinopathy: characterization and translational implications

IM Nawaz, S Rezzola, A Cancarini, A Russo… - Progress in retinal and …, 2019 - Elsevier
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

[HTML][HTML] Proteomic biomarkers of retinal inflammation in diabetic retinopathy

H Youngblood, R Robinson, A Sharma… - International journal of …, 2019 - mdpi.com
Diabetic retinopathy (DR), a sight-threatening neurovasculopathy, is the leading cause of
irreversible blindness in the developed world. DR arises as the result of prolonged …

MALAT1: an epigenetic regulator of inflammation in diabetic retinopathy

S Biswas, AA Thomas, S Chen, E Aref-Eshghi… - Scientific reports, 2018 - nature.com
Despite possessing limited protein-coding potential, long non-coding RNAs (lncRNAs) have
been implicated in a myriad of pathologic conditions. Most well documented in cancer, one …