Combinatorial interactions of biotic and abiotic stresses in plants and their molecular mechanisms: systems biology approach

AK Dangi, B Sharma, I Khangwal, P Shukla - Molecular biotechnology, 2018 - Springer
Plants are continually facing biotic and abiotic stresses, and hence, they need to respond
and adapt to survive. Plant response during multiple and combined biotic and abiotic …

Pan-genome analysis of Clostridium botulinum reveals unique targets for drug development

T Bhardwaj, P Somvanshi - Gene, 2017 - Elsevier
Clostridium botulinum, a formidable pathogen is responsible for the emerging cause of food
poisoning cases on the global canvas. The endemicity of bacterium Clostridium botulinum is …

Comparative assessment of the therapeutic drug targets of C. botulinum ATCC 3502 and C. difficile str. 630 using in silico subtractive proteomics approach

T Bhardwaj, S Haque… - Journal of Cellular …, 2019 - Wiley Online Library
Growing antimicrobial resistance of the pathogens against multiple drugs posed a serious
threat to the human health worldwide. This fueled the need of identifying the novel …

Aspartate‐β‐semialdeyhyde dehydrogenase as a potential therapeutic target of Mycobacterium tuberculosis H37Rv: Evidence from in silico elementary mode …

S Khan, P Somvanshi, T Bhardwaj… - Journal of cellular …, 2018 - Wiley Online Library
The emergence of multi‐drug resistant strains and co‐occurrence of tuberculosis with HIV
creates a major burden to the human health globally. Failure of primary antibacterial therapy …

Inhibition of C298S mutant of human aldose reductase for antidiabetic applications: Evidence from in silico elementary mode analysis of biological network model

S Khan, T Bhardwaj, P Somvanshi… - Journal of cellular …, 2018 - Wiley Online Library
Human aldose reductase (hAR) is the key enzyme in sorbitol pathway of glucose utilization
and is implicated in the etiology of secondary complications of diabetes, such as …

Bioinformatics: a way forward to explore “plant omics”

TS Mehboob-ur-Rahman… - Bioinformatics …, 2016 - books.google.com
Bioinformatics, a computer-assisted science aiming at managing a huge volume of genomic
data, is an emerging discipline that combines the power of computers, mathematical …

Association of inflammatory bowel disease with arthritis: evidence from in silico gene expression patterns and network topological analysis

A Verma, P Somvanshi, S Haque, B Rathi… - Interdisciplinary Sciences …, 2019 - Springer
Inflammatory bowel disease (IBD) is an idiopathic prolonged ailment accountable for
inflammatory conditions of the intestine. Moreover, arthritis is responsible for joints' stiffness …

A computational approach using mathematical modeling to assess the peptidoglycan biosynthesis of Clostridium botulinum ATCC 3502 for potential drug targets

T Bhardwaj, P Somvanshi - Gene Reports, 2018 - Elsevier
C. botulinum ATCC 3502 is an obligate rod-shaped spore forming anaerobe causing food
poisoning cases worldwide. The increased burden of sporadic hospital outbreaks reflects …

Relevance of Bioinformatics and Database in Omics Study

R Shankar, V Dwivedi, GC Arya - … and Global Food Security Volume 1, 2021 - Springer
Bioinformatics is an interdisciplinary branch of biological sciences that assists biologists to
interpret and extract the biological information from the omics data. The biological …

[PDF][PDF] APPLICATION OF SYSTEMS BIOLOGY APPROACH FOR INVESTIGATION OF PAN GENOME AND PHYLOGENETICS IN VARIOUS STRAINS OF …

P Singh, D Verma - Journal of microbiology, biotechnology and …, 2020 - office2.jmbfs.org
Anaplasma phagocytophilum, has been observed as an emerging human pathogen of
public health importance and is commonly transmitted to humans by tick bites. The …