Gut microbiota-derived vitamins–underrated powers of a multipotent ally in psychiatric health and disease

L Rudzki, TW Stone, M Maes, B Misiak… - Progress in Neuro …, 2021 - Elsevier
Despite the well-established roles of B-vitamins and their deficiencies in health and disease,
there is growing evidence indicating a key role of those nutrients in functions of the central …

The impact of gut microbiota-derived metabolites in autism spectrum disorders

LN Peralta-Marzal, N Prince, D Bajic, L Roussin… - International journal of …, 2021 - mdpi.com
Autism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders characterised by
behavioural impairment and deficiencies in social interaction and communication. A recent …

Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide

RL Loo, Q Chan, JK Nicholson… - Journal of Proteome …, 2022 - ACS Publications
Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote
organisms as well as in the environment, reflecting their fundamental importance in …

Potential role of L-carnitine in autism spectrum disorder

A Kępka, A Ochocińska, S Chojnowska… - Journal of Clinical …, 2021 - mdpi.com
L-carnitine plays an important role in the functioning of the central nervous system, and
especially in the mitochondrial metabolism of fatty acids. Altered carnitine metabolism …

The accumulation and molecular effects of trimethylamine N-oxide on metabolic tissues: It's not all bad

ES Krueger, TS Lloyd, JS Tessem - Nutrients, 2021 - mdpi.com
Since elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with
increased risk of cardiovascular disease (CVD), TMAO research among chronic diseases …

Clinical significance and potential role of trimethylamine N-oxide in neurological and neuropsychiatric disorders

S Mudimela, NK Vishwanath, A Pillai, R Morales… - Drug discovery today, 2022 - Elsevier
In the past three decades, research on the gut microbiome and its metabolites, such as
trimethylamines (TMA), trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs) …

Machine learning algorithms applied to predict autism spectrum disorder based on gut microbiome composition

JM Olaguez-Gonzalez, I Chairez, L Breton-Deval… - Biomedicines, 2023 - mdpi.com
The application of machine learning (ML) techniques stands as a reliable method for aiding
in the diagnosis of complex diseases. Recent studies have related the composition of the gut …

Connections between serum Trimethylamine N-Oxide (TMAO), a gut-derived metabolite, and vascular biomarkers evaluating arterial stiffness and subclinical …

MS Mihuta, C Paul, A Borlea, CM Roi… - Frontiers in …, 2023 - frontiersin.org
Introduction Childhood obesity leads to early subclinical atherosclerosis and arterial
stiffness. Studying biomarkers like trimethylamine N-oxide (TMAO), linked to cardio …

Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation

Y Luo, P Zhao, M Dou, J Mao, G Zhang, Y Su… - …, 2021 - Elsevier
Increasing evidence indicates that gut microbiota and its metabolites can influence the brain
function and the related behaviors. Trimethylamine N-oxide (TMAO), an indirect metabolite …

Dietary pattern in autism increases the need for probiotic supplementation: A comprehensive narrative and systematic review on oxidative stress hypothesis

M Zarezadeh, M Mahmoudinezhad, B Hosseini… - Clinical Nutrition, 2023 - Elsevier
Autism spectrum disorders (ASDs) are associated with specific dietary habits, including
limited food selection and gastrointestinal problems, resulting in an altered gut microbiota …