Systems biology in cardiovascular disease: a multiomics approach

A Joshi, M Rienks, K Theofilatos, M Mayr - Nature Reviews Cardiology, 2021 - nature.com
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

MicroRNAs in cardiovascular disease

T Barwari, A Joshi, M Mayr - Journal of the American College of Cardiology, 2016 - jacc.org
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …

Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

D De Gonzalo-Calvo, ID Benitez, L Pinilla… - Translational …, 2021 - Elsevier
We aimed to examine the circulating microRNA (miRNA) profile of hospitalized COVID-19
patients and evaluate its potential as a source of biomarkers for the management of the …

Circulating noncoding RNAs as biomarkers of cardiovascular disease and injury

J Viereck, T Thum - Circulation research, 2017 - Am Heart Assoc
The discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on
mammalian genomes and transcriptomes, as well as their organization and regulation …

Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review

R Navickas, D Gal, A Laucevičius… - Cardiovascular …, 2016 - academic.oup.com
The aim of the present study is to identify microRNAs (miRs) with high potential to be used
as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis …

Methodological challenges in utilizing mi RNA s as circulating biomarkers

L Moldovan, KE Batte, J Trgovcich… - Journal of cellular …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …

RNA-Seq identifies circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as potential biomarkers for acute ischemic stroke

S Tiedt, M Prestel, R Malik, N Schieferdecker… - Circulation …, 2017 - Am Heart Assoc
Rationale: Currently, there are no blood-based biomarkers with clinical utility for acute
ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type …

Activated platelets can deliver mRNA regulatory Ago2• microRNA complexes to endothelial cells via microparticles

B Laffont, A Corduan, H Plé, AC Duchez… - Blood, The Journal …, 2013 - ashpublications.org
Platelets play a crucial role in the maintenance of hemostasis, as well as in thrombosis.
Upon activation, platelets release small membrane-bound microparticles (MPs) containing …

MiRNA and LncRNA as potential biomarkers in triple-negative breast cancer: a review

SR Volovat, C Volovat, I Hordila, DA Hordila… - Frontiers in …, 2020 - frontiersin.org
Noncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs
(miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 …

Circulating microRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes

P Willeit, P Skroblin, AR Moschen, X Yin… - Diabetes, 2017 - Am Diabetes Assoc
MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its
relevance to the long-term risk of develo** metabolic disorders is unknown. We therefore …