Next generation sequencing of SARS-CoV-2 genomes: challenges, applications and opportunities

M Chiara, AM D'Erchia, C Gissi… - Briefings in …, 2021 - academic.oup.com
Various next generation sequencing (NGS) based strategies have been successfully used in
the recent past for tracing origins and understanding the evolution of infectious agents …

Nanopore technology and its applications in gene sequencing

B Lin, J Hui, H Mao - Biosensors, 2021 - mdpi.com
In recent years, nanopore technology has become increasingly important in the field of life
science and biomedical research. By embedding a nano-scale hole in a thin membrane and …

Real-time, portable genome sequencing for Ebola surveillance

J Quick, NJ Loman, S Duraffour, JT Simpson, E Severi… - Nature, 2016 - nature.com
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for
over 28,599 cases and more than 11,299 deaths. Genome sequencing in viral outbreaks is …

Virus genomes reveal factors that spread and sustained the Ebola epidemic

G Dudas, LM Carvalho, T Bedford, AJ Tatem, G Baele… - Nature, 2017 - nature.com
Abstract The 2013–2016 West African epidemic caused by the Ebola virus was of
unprecedented magnitude, duration and impact. Here we reconstruct the dispersal …

Molecular evidence of sexual transmission of Ebola virus

SE Mate, JR Kugelman, TG Nyenswah… - … England Journal of …, 2015 - Mass Medical Soc
A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD)
to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola …

The evolution of Ebola virus: Insights from the 2013–2016 epidemic

EC Holmes, G Dudas, A Rambaut, KG Andersen - Nature, 2016 - nature.com
The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented
magnitude and changed our perspective on this lethal but sporadically emerging virus. This …

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time

KG Barnes, AE Lachenauer, A Nitido, S Siddiqui… - Nature …, 2020 - nature.com
Recent outbreaks of viral hemorrhagic fevers (VHFs), including Ebola virus disease (EVD)
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …

Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone

DJ Park, G Dudas, S Wohl, A Goba, SLM Whitmer… - Cell, 2015 - cell.com
Summary The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona
variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights …

Diagnosis of Ebola virus disease: past, present, and future

MJ Broadhurst, TJG Brooks… - Clinical microbiology …, 2016 - Am Soc Microbiol
Laboratory diagnosis of Ebola virus disease plays a critical role in outbreak response efforts;
however, establishing safe and expeditious testing strategies for this high-biosafety-level …

[HTML][HTML] Ebola virus glycoprotein with increased infectivity dominated the 2013–2016 epidemic

WE Diehl, AE Lin, ND Grubaugh, LM Carvalho, K Kim… - Cell, 2016 - cell.com
The magnitude of the 2013–2016 Ebola virus disease (EVD) epidemic enabled an
unprecedented number of viral mutations to occur over successive human-to-human …