Nanozyme-based strategies for efficient theranostics of brain diseases

R Xu, S Zhang, P Wang, R Zhang, P Lin, Y Wang… - Coordination Chemistry …, 2024 - Elsevier
Oxidative stress emerges as a critical mechanism underlying the development and
progression of various brain diseases, arising from either increased generation of reactive …

Tailoring the surface and composition of nanozymes for enhanced bacterial binding and antibacterial activity

J Hou, Y **anyu - Small, 2023 - Wiley Online Library
With the advantages of diverse structures, tunable enzymatic activity, and high stability,
nanozymes are widely used in medicine, chemistry, food, environment, and other fields. As …

Coordination-driven self-assembly strategy-activated Cu single-atom nanozymes for catalytic tumor-specific therapy

J Zhou, D Xu, G Tian, Q He, X Zhang… - Journal of the …, 2023 - ACS Publications
How to optimize the enzyme-like catalytic activity of nanozymes to improve their applicability
has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven …

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

S Zhang, Y Li, S Sun, L Liu, X Mu, S Liu, M Jiao… - Nature …, 2022 - nature.com
Regenerable nanozymes with high catalytic stability and sustainability are promising
substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective …

Amorphizing metal selenides-based ROS biocatalysts at surface nanolayer toward ultrafast inflammatory diabetic wound healing

Y Deng, Y Gao, T Li, S **ao, M Adeli, RD Rodriguez… - ACS …, 2023 - ACS Publications
The microenvironments with high reactive-oxygen-species (ROS) levels, inflammatory
responses, and oxidative-stress effects in diabetic ulcer wounds, leading to poor …

Chemiluminescent carbon nanodots for dynamic and guided antibacteria

JF Han, Q Lou, ZZ Ding, GS Zheng, QC Ni… - Light: Science & …, 2023 - nature.com
Advanced antibacterial technologies are needed to counter the rapid emergence of drug-
resistant bacteria. Image-guided therapy is one of the most promising strategies for …

Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury

B Huang, T Tang, SH Chen, H Li, ZJ Sun… - Nature …, 2023 - nature.com
The blood-brain barrier breakdown, as a prominent feature after traumatic brain injury,
always triggers a cascade of biochemical events like inflammatory response and free radical …

Engineering antioxidative cascade metal-phenolic nanozymes for alleviating oxidative stress during extracorporeal blood purification

Z Wei, G Peng, Y Zhao, S Chen, R Wang, H Mao… - ACS …, 2022 - ACS Publications
Oxidative stress is a compelling risk factor in chronic kidney diseases and is further
aggravated for individuals during extracorporeal blood purification, ultimately leading to …

Bimetallic Nanozyme: A Credible Tag for In Situ-Catalyzed Reporter Deposition in the Lateral Flow Immunoassay for Ultrasensitive Cancer Diagnosis

X Meng, W Zuo, P Wu, Y Song, GJ Yang, S Zhang… - Nano Letters, 2023 - ACS Publications
The lateral flow immunoassay (LFIA) is a sought-after point-of-care testing platform, yet the
insufficient sensitivity of the LFIA limits its application in the detection of tumor biomarkers …

Approaches to improving the selectivity of nanozymes

SV Somerville, Q Li, J Wordsworth, S Jamali… - Advanced …, 2024 - Wiley Online Library
Nanozymes mimic enzymes and that includes their selectivity. To achieve selectivity,
significant inspiration for nanoparticle design can come from the geometric and molecular …