Cryptosporidium pathogenicity and virulence

M Bouzid, PR Hunter, RM Chalmers… - Clinical microbiology …, 2013 - Am Soc Microbiol
Cryptosporidium is a protozoan parasite of medical and veterinary importance that causes
gastroenteritis in a variety of vertebrate hosts. Several studies have reported different …

Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease

FS Machado, WO Dutra, L Esper, KJ Gollob… - Seminars in …, 2012 - Springer
Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …

Mechanisms of Trypanosoma cruzi persistence in Chagas disease

F Nagajyothi, FS Machado, BA Burleigh… - Cellular …, 2012 - Wiley Online Library
Trypanosoma cruzi infection leads to development of chronic Chagas disease. In this article,
we provide an update on the current knowledge of the mechanisms employed by the …

[HTML][HTML] Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead

KM Bonney, DM Engman - The American journal of pathology, 2015 - Elsevier
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of individuals infected with the protozoan parasite Trypanosoma cruzi. Since the …

Chagas heart disease pathogenesis: one mechanism or many?

KM Bonney, DM Engman - Current molecular medicine, 2008 - ingentaconnect.com
Chagas heart disease (CHD), caused by the protozoan parasite Trypanosoma cruzi, is the
leading cause of infectious myocarditis in the world. The etiology of CHD is unclear and …

Prostanoid receptors

T Hirata, S Narumiya - Chemical reviews, 2011 - ACS Publications
Prostanoids are potent oxygenated lipid molecules that contribute to a wide variety of
physiological responses and pathological processes. They are generated by the metabolism …

Perspectives on Trypanosoma cruzi–induced heart disease (Chagas disease)

HB Tanowitz, FS Machado, LA Jelicks, J Shirani… - Progress in …, 2009 - Elsevier
Chagas disease is caused by the parasite Trypanosoma cruzi. It is a common cause of heart
disease in endemic areas of Latin America. The year 2009 marks the 100th anniversary of …

Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms

MA Rossi, HB Tanowitz, LM Malvestio… - PLoS neglected …, 2010 - journals.plos.org
This review focuses on the short and bewildered history of Brazilian scientist Carlos
Chagas's discovery and subsequent developments, the anatomopathological features of …

Endothelin-1 and its role in the pathogenesis of infectious diseases

BD Freeman, FS Machado, HB Tanowitz… - Life sciences, 2014 - Elsevier
Endothelins are potent regulators of vascular tone, which also have mitogenic, apoptotic,
and immunomodulatory properties (Rubanyi and Polokoff, 1994; Kedzierski and …

Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi

AMM Santi, JM Ribeiro, JL Reis-Cunha… - PLoS neglected …, 2022 - journals.plos.org
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a serious chronic parasitic
disease, currently treated with Nifurtimox (NFX) and Benznidazole (BZ). In addition to high …