The proteasome is an abundant multi-enzyme complex that provides the main pathway for
degradation of intracellular proteins in eukaryotic cells. As such, it controls the levels of …

The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor
suppressor. Amplification of mdm2 or increased expression by unknown mechanisms …

Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

We propose a mathematical model for mitochondria-dependent apoptosis, in which kinetic
cooperativity in formation of the apoptosome is a key element ensuring bistability. We …

The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as
a ubiquitin ligase (E3) to target p53 for degradation. We have identified a family of small …

Background The proteasome plays a vital role in the physiology of glioblastoma (GBM), and
proteasome inhibition can be used as a strategy for treating GBM. Marizomib is a second …

The 97-kDa valosin-containing protein (p97 or VCP) is a type-II AAA (A TPases a ssociated
with a variety of a ctivities) ATPases, which are characterized by possessing two conserved …

We examined the influence of ROS on the phosphorylation and complex formation of Bcl‐2
family proteins in Mn‐superoxide dis‐mutase (SOD) antisense‐transfected squamous cell …

The highly conserved eukaryotic ubiquitin–proteasome system (UP-S) plays a pivotal role in
protein homeostasis and is critical in regulating normal and cancer-related cellular …

During the past decade, it has become apparent that a set of ostensibly unrelated
neurodegenerative diseases, including Parkinson's disease and Huntington's disease …