Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Does it matter what we eat for our mental health? Accumulating data suggests that this may
indeed be the case and that diet and nutrition are not only critical for human physiology and …

A systematic review of published toxicology and human intervention studies was performed
to characterize potential hazards associated with consumption of green tea and its …

Abstract Epigallocatechin-3-gallate (EGCG) is a candidate for treatment of Alzheimer's
disease (AD) but its inherent instability limits bioavailability and effectiveness. We found that …

Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

Natural antioxidants are a very large diversified family of molecules classified by activity
(enzymatic or nonenzymatic), chemical-physical properties (eg, hydrophilic or lipophilic) …

Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …

Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …