Animal models of epilepsy: use and limitations

L Kandratavicius, PA Balista… - Neuropsychiatric …, 2014 - Taylor & Francis
Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?

G Curia, C Lucchi, J Vinet, F Gualtieri… - Current medicinal …, 2014 - ingentaconnect.com
Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …

The piriform, perirhinal, and entorhinal cortex in seizure generation

MS Vismer, PA Forcelli, MD Skopin, K Gale… - Frontiers in neural …, 2015 - frontiersin.org
Understanding neural network behavior is essential to shed light on epileptogenesis and
seizure propagation. The interconnectivity and plasticity of mammalian limbic and …

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …

The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65 years

II Poletaeva, NM Surina, ZA Kostina, OV Perepelkina… - Epilepsy & Behavior, 2017 - Elsevier
The more recent history and main experimental data for the Krushinsky–Molodkina (KM)
audiogenic rat strain are presented. The strain selection started in late 1940. Now this strain …

The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: history and perspectives

N Garcia-Cairasco, EHL Umeoka, JAC de Oliveira - Epilepsy & Behavior, 2017 - Elsevier
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …

Increased TRPV1 channels and FosB protein expression are associated with chronic epileptic seizures and Anxiogenic-like behaviors in a preclinical model of …

W Lazarini-Lopes, GK Silva-Cardoso… - Biomedicines, 2022 - mdpi.com
Epilepsies are neurological disorders characterized by chronic seizures and their related
neuropsychiatric comorbidities, such as anxiety. The Transient Receptor Potential Vanilloid …

A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy

H Suzuki, K Katayama, M Takenaka… - Genes, Brain and …, 2009 - Wiley Online Library
The lde/lde rat is characterized by dwarfism, postnatal lethality, male hypogonadism, a high
incidence of epilepsy and many vacuoles in the hippocampus and amygdala. We used a …

Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features

LV Vinogradova - Epilepsy & Behavior, 2017 - Elsevier
Human epilepsy is usually considered to result from cortical pathology, but animal studies
show that the cortex may be secondarily involved in epileptogenesis, and cortical seizures …

Cannabinoid receptor type 1 (CB1R) expression in limbic brain structures after acute and chronic seizures in a genetic model of epilepsy

W Lazarini-Lopes, RMP da Silva-Júnior… - Frontiers in Behavioral …, 2020 - frontiersin.org
The endocannabinoid system (ECS) is related to several physiological processes,
associated to the modulation of brain excitability, with impact in the expression of …