Plethora of research has shed light on the critical role of synaptic dysfunction in various
neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's …

Background Dementia is caused by a variety of neurodegenerative diseases and is
associated with a decline in memory and other cognitive abilities, while inflicting an …

Background Accurate prediction of cerebral amyloidosis with easily available indicators is
urgently needed for diagnosis and treatment of Alzheimer's disease (AD). Methods We …

Amyloid beta (Aβ) oligomers are the most neurotoxic aggregates causing neuronal death
and cognitive damage. A detailed elucidation of the aggregation pathways from oligomers to …

Neurodegenerative diseases, including Alzheimer's disease (AD), pose a significant and
urgent challenge to healthcare systems worldwide. With an increasing life expectancy, these …

Previous works imply that involving brainstem in neuropathological studies of Alzheimer's
disease (AD) is of clinically significant. This work constructs a comprehensive neural mass …

Though Alzheimer's disease (AD) is the most common cause of dementia, complete disease-
modifying treatments are yet to be fully attained. Until recently, transgenic mice constituted …

Background: Alzheimer's disease (AD) is the most common form of dementia representing
from 60% to 70% of the cases globally. It is a multifactorial disease that, among its many …

Objective: To characterize the specific metabolomics profiles in the outer membrane vesicles
(OMVs) of patients with Alzheimer's Disease (AD) and to explore potential metabolic …

Alzheimer's disease (AD) is a serious neurodegenerative disorder that results in cognitive
deterioration, amnesia, and alterations in behavior, rendering it a significant issue in public …